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Differences between adults and children Children with serious illness or injury are less likely to medicine plus generic 5mg dulcolax arrive by ambulance than adults of similar case severity symptoms als order dulcolax 5 mg online, simply because they are easier to medicine in the civil war 5mg dulcolax fast delivery transport, so caregivers often feel they will arrive at the hospital more quickly if they bring the child themselves. Combined with a lower representation in the general population and a lower incidence of serious illness and injury in children compared with adults, pre-hospital staff are exposed to relatively fewer paediatric cases than adult ones. Paediatric calls constitute only 5-30% of ambulance activations (depending on the country). In addition, most pre-hospital staff receive much less training in the care of children than they receive for adults. As a result, confidence, and sometimes competence, is much less, particularly in common diseases which affect only children. Equipment and medication issues often arise because of the different sizes, doses and formulations needed, while carrying space and weight are usually limited in the pre-hospital setting. Ensuring safe paediatric pre-hospital care the likelihood of members of the public initiating a call for ambulance assistance varies greatly between different countries. Where possible, staff at schools or day care centres, as well as members of the general public, should be trained in providing first aid and in activation of pre-hospital services. On arrival at the scene, pre-hospital staff are often the first clinicians who may recognise evidence and clues of child abuse or neglect (scene awareness). This skill should be encouraged and reporting systems taught to pre-hospital staff, as well as encouragement to promote primary prevention of paediatric illness and injuries. There are different types of pre-hospital clinicians found in international pre-hospital services. Examples include Emergency Medical Technicians, Paramedics, Intensive Care Paramedics, Physicians (pre-hospital care doctors), etc. In providing training, they should be mindful that confidence and competence is likely to be lower than for adult clinical practice (see above). For basic 1 level care, the Paediatric Assessment Triangle provides a useful framework to spot a sick child. For more advanced pre-hospital staff a more complete assessment can take place such 2 as the "3 minute toolkit". The core skills needed for paediatric assessment are: Eliciting a history from the family or carers and from the child, using age appropriate language Dealing calmly with carers or members of the pubic, who are often under stress or may be emotional, and calming the child, to optimise assessment Performing a physical examination appropriate to the age of the child. Medical treatment All providers of pre-hospital services must define the level of medical treatment their organization expects different levels of staff to provide. Factors to be taken into consideration will include: level of provider training. Good clinical decision support algorithms should take these variables into consideration. Therefore, for safety, memory aids should be available to assist 3 pre-hospital staff in these calculations. Broselow paediatric emergency tape and pocket charts (electronic or printed folders). These should contain common resuscitation and anaesthetic drug dosages and paediatric treatment protocols. Equipment also needs to be varied according to size (but the amount of equipment carried must not compromise patient safety. Communication between services Clear communication channels between pre-hospital and hospital sites are vital when transporting sick children to a health facility. This communication includes the following aspects: Transport contracts or agreements between the pre-hospital service and the receiving hospitals. These should be based on the local paediatric capabilities available at each destination within the local network, i. This usually requires real time information of paediatric capacity across the network Standardised formats of relaying clinical information. Pre-hospital responders with advanced training must be competent in advanced life support for infants, children and adolescents. A rapid method for estimating weight and resuscitation drug dosages from length in the pediatric age group.

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The behavioral response of organisms to symptoms 2dp5dt 5 mg dulcolax sale the vector of gravity symptoms hiatal hernia order 5 mg dulcolax overnight delivery, which can have a negative or positive value-that is symptoms 24 hour flu buy 5mg dulcolax, move up (negative) or down (positive). The behavioral response of organisms to light, which can have a negative or positive value-that is, move away from (negative) or toward (positive). A "candidate gene approach," which implicates previously characterized genes with a novel phenotype. An emerging biological framework that promotes a holistic approach to understanding complex biological systems, based on the idea that complex biological systems have irreducible emergent properties that cannot be understood by studies of simpler individual elements. Genetic studies using systems biology, especially in the context of non-Mendelian complex phenotypes, based on the principle that understanding complex phenotypes such as behavior depends on understanding interrelationships among genotypes and phenotypes at the organismal level. Despite this ubiquity, finding a simple and common description of behavior is elusive, perhaps in part because the term behavior covers so many different actions. This staggering behavioral diversity across the animal kingdom and the inherent phenotypic range associated with behavior have often led to a common belief that behaviors are unique phenotypes that cannot be explained within the general biological framework. The fourth important scientific development was the emergence of modern neuroscience. This field served as the foundation for understanding how multicellular animals can integrate and process stimuli, and translate them into an action, a "behavior. The rest of this chapter presents the theories and empirical data that support the role of genes and evolution in behavior and explains the synergistic role behavioral genetics plays in modern evolutionary thought. Furthermore, as the field of molecular genetics matured, it became clear that many behavioral phenotypes are complex and do not follow simple single-gene Mendelian rules. While the mounting evidence supports the hypothesis that heredity and genetics have an influence on behaviors, most behaviors show a continuous distribution of values. This model suggests that a specific behavioral phenotype can be stretched in multiple directions dependent on the strength of the various internal and external stimuli relevant to the phenotype in a species-specific context. Moreover, as is discussed toward the end of this chapter, certain plastic phenotypic alternatives can become fixed across generations via nongenomic, epigenetic mechanisms. First coined by Galton in his book English Men of Science: Their Nature and Their Nurture (1874)-and despite his perspective that both nature and nurture are important in the development of behavior-the expression "nature versus nurture" became synonymous with the controversies associated with the field of behavioral genetics. The introduction of heredity, and later genetics, to the fields of animal behavior and evolution met with much resistance, likely stemming from earlier views by philosophers such as John Locke, who suggested that all people are born as a tabula rasa, or blank slate. The tabula rasa postulate asserted that all humans are born equal in terms of their cognitive and behavioral capacities, and it is only their experiences that shape who they become. In contrast, many of the early geneticists in the United States and Europe promoted the hereditarian (nature) view of behavior, which was dominant for most of the first half of the twentieth century. This interpretation resulted in the application of Mendelian genetics, sometimes in the most absurd ways, to many human and animal behavioral traits. These deterministic views changed rapidly during the 1950s as behaviorism became a popular philosophical view of human and animal behavior. Most modern-day researchers who study human or animal behavior would agree that the nature versus nurture dichotomy is, in fact, oversimplified and archaic, although it is still prevalent in the scientific literature. No organism develops without genes (nature), and no organism develops in the absence of an environment Despite the tendency of people (and newspapers) to speak of "genes for behavior," specific genes might not necessarily encode directly for a specific behavior but rather are shaped by evolution to set physiological and physical constraints on the expression of behavioral phenotypes. Unfortunately, and perhaps confusingly, geneticists frequently assign specific "functions" for their genes, in ways that simplify their long-term research goals but that lead to the perception that specific genes cause specific behaviors. For example, the scientific literature contains descriptions of genes classified as a "developmental gene" or a "cancer gene. It is the biochemical function of these macromolecules, and the cellular processes they fuel, that drive processes such as the occurrence of cancer, normal development, or the expression of a specific behavioral phenotype (Robinson et al. Modern neuroscience teaches that in all multicellular animals, a behavior is the product of the nervous system, a complex and highly specialized organ made of many individual neurons organized in stereotypical neuronal circuits. An underlying assumption in his studies was that multiple independent genes contribute to behavioral phenotypes and that allelic variations in each locus contribute a defined fraction of the overall behavioral variations in a population. One of his studies that best illustrated this approach was a long-term selection study of flies that showed a strong positive or negative response to gravity (geotaxis). Wild-type flies tend to be somewhat negatively geotactic (run "up" when disturbed). Hirsch selected for genetically homogeneous Drosophila strains that showed either extreme positive or negative geotaxis behaviors. His conclusions were that even for a relatively simple behavior such as geotaxis, many genes contribute to the genetic divergence between the two strains and the responsible genes are likely distributed across all three chromosomes.

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The neutral theory emphasizes random fixation of neutral or nearly neutral mutations (see chapter V treatment for gout purchase dulcolax 5mg line. Under such a model medications used to treat ptsd generic 5mg dulcolax fast delivery, the rate of substitution is equal to treatment of lyme disease buy dulcolax 5 mg on-line the neutral mutation rate, independent of factors such as environmental change and population size variation. If the mutation rate is similar and the function of a protein remains the same across species (so that the same proportion of mutations are neutral), a constant substitution rate is expected. Rate differences among proteins are explained by the presupposition that different proteins are under different functional constraints, with a different proportion of amino acids experiencing neutral mutations. The neutral theory is not the only mechanism compatible with clocklike evolution; neither does the neutral theory always predict a molecular clock. Under the clock assumption, the expected distance between sequences increases linearly with time of divergence. When external information about the geological ages of one or more divergence events on a phylogeny is available, based on the fossil record or certain geological events, the distances between sequences or the branch lengths on the tree can be converted into absolute geological times. The earliest application of the clock to estimate divergence times was by Zuckerkandl and Pauling in 1962, who used an approximate clock to date duplication events among a, b, g, and d globins of the hemoglobin family. The outcomes of molecular clock analyses have often produced controversies, usually because the molecular dates are at odds with the fossil record. Fossil forms of metazoan phyla appear as an "explosion" around 540 million years ago in the early Cambrian, but most molecular estimates of the ages of these divergence events have been much older, sometimes twice as old. Part of the discrepancy between molecular and fossil data is due to the incompleteness of the fossil record. Fossils provide information concerning the date by which Molecular Clock Dating a newly diverging lineage had developed diagnostic morphological characters. There may be a lag between the time that a lineage arose and the age of the first fossil with the derived traits of the descendants. Molecular dating, in contrast, infers ages of nodes (divergence events among ancestral lineages) in a phylogenetic tree. Fossil-based dates therefore tend to be younger than those derived from molecular data. Another source of discrepancy can be inaccuracies and deficiencies in molecular time estimation. Despite sometimes acrimonious controversies, the interactions between molecules and fossils have been a driving force in this research area, since they have prompted reinterpretations of fossils, critical evaluations of molecular dating techniques, and the development of more advanced analytical methods. Our focus in this chapter is on statistical methods for testing the clock hypothesis, and on likelihood and Bayesian methods for dating species divergence events under global and local clock models. In such analyses, fossils are used to calibrate the clock, that is, to translate sequence distances into absolute geological times and substitution rates. One can use the dates at which particular viruses were isolated to calibrate the clock and to estimate divergence times, using essentially the same techniques as discussed here. Indeed, such dated viral sequences are sometimes referred to as "fossil sequences," although most such samples were isolated during the last 100 years and are not true fossils. The relative rate test compares the rates of evolution in two species (a and b) using a third species o as the out-group. Several statistical tests have been developed to examine whether the rate of molecular evolution is constant over time. The simplest, known as the relative rate test, examines whether two species a and b evolve at the same rate by using a third out-group species o (figure 1). As species a and b share the same common ancestor y, the distance from y to a should equal the distance from y to b if the hypothesis of the molecular clock is true: dya = dyb (figure 1A). Equivalently, one can formulate the clock hypothesis relative to the out-group as dao = dbo and test whether the difference between the two calculated distances d = dao ­ dbo is significantly different from 0. The sequence distances and their variances can be calculated under any model of nucleotide or amino acid substitution, and the calculated d and its standard error can be used to construct a test based on the normal distribution. It is also possible to conduct this relative-rate test using a likelihood ratio test. The null model assumes the clock and involves two parameters (t1 and t2 in figure 1A).

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This report shows that many young genes have evolved essential functions in development in Drosophila 5 medications that affect heart rate dulcolax 5mg with visa. Thus the treatment 2014 online dulcolax 5 mg line, the developmental program of a species can evolve rapidly with the birth of species-specific and lineage-specific components of the genetic systems underlying development symptoms hiv generic dulcolax 5 mg line. This report reveals bidirectional gene trafficking between the X and autosomes in the human genome. In one direction, X-linked parental genes were copied onto autosomes and evolved testis-biased expression; in the other direction, an excess of female genes and nonsex-related genes were moved to the X. The evolutionary products derived from exon shuffling, chimeric genes, have since been widely observed. Evolutionary forces responsible for expression divergence Genetic changes affecting either the function or regulation of a gene product can contribute to phenotypic evolution. Studies of evolutionary mechanisms have historically focused on changes in protein-coding sequences, but during the last decade, multiple lines of evidence have shown that changes in gene expression are at least equally important. The last few years have brought great progress in understanding the genetic basis of expression differences within and between species. From a growing collection of single-gene case studies and comparative analyses of gene expression on a genomic scale, common themes and patterns in regulatory evolution have begun to emerge. Discovering this conservation was a boon to the medical genetics community, because it justified the use of model organisms such as fruit flies and mice to investigate human disease, but also presented a paradox: How can divergent traits be constructed using conserved genes? Comparing expression in samples from three humans, three chimpanzees, and one orangutan showed extensive variation within both humans and chimpanzees. The extent of expression divergence between humans and chimpanzees was smaller than the divergence observed when either of these species was compared to the orangutan, suggesting that expression divergence correlates with phylogenetic distance. In the samples derived from brains, one human was found to differ more from another human than from a chimpanzee, but this type of relationship is rare: polymorphic gene expression within a species is typically less extensive than divergent gene expression between species. In a slightly different experiment, macaques were used as an out-group, and gene expression in humans was found to have evolved faster in the brain than in the liver or blood. Although it is tempting to speculate that this apparently accelerated evolution of gene expression in the human brain may have contributed to the evolution of human-specific cognitive abilities, a reanalysis of the answer to this question is, in part, by modifying the regulation of gene expression. Davidson proposed a theory for the regulation of gene expression in eukaryotic cells. They viewed gene regulation as integral to evolution and suggested that differences among species could be attributable to changes in the regulation of gene expression. Wilson published a seminal paper showing that the amino acid sequences of homologous human and chimpanzee proteins appeared to be more than 99 percent identical. Based on this result, they argued that the degree of protein divergence was insufficient to account for the extensive morphological, physiological, and behavioral differences between these two species. Despite these (and similar) predictions more than 35 years ago, the idea that changes in gene expression might be a common source of phenotypic divergence did not gain mainstream acceptance among evolutionary biologists until after the turn of the twenty-first century. Seeds of this acceptance were sown when developmental biologists, using newly developed tools for visualizing gene expression, began comparing expression among species. This approach catalyzed the expansion of evolutionary developmental biology, a field of research known today as evo-devo. Such correlations suggest that the genetic changes responsible for altered gene expression might be the same changes responsible for altered phenotypes. These low-throughput types of studies were (and Evolution of Gene Expression these data that more completely modeled the sources of variance in the experiment found more genes with differential expression in the liver than in the brain between humans and chimpanzees. This example illustrates the potential tremendous impact of statistical analysis methods on the conclusions drawn from this type of work. Particularly problematic in this case (and in other cases where a microarray with sequences from one species is used to compare expression between species) is accounting for the effects of sequence divergence between the microarray probes and the heterologous species. To understand the types of sequences in the genome that can be mutated to alter gene expression, one must consider the molecular mechanisms controlling transcriptional and posttranscriptional regulation of gene expression. Within prokaryotes and eukaryotes, these mechanisms are highly conserved, but they differ significantly between the two groups.

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The conversation between the doctor and patient reminds us that despite our efforts to treatment ear infection discount 5mg dulcolax with mastercard control nature symptoms for strep throat dulcolax 5 mg without prescription, we remain targets for organisms that have evolved medications multiple sclerosis buy 5 mg dulcolax overnight delivery, and continue to evolve, to exploit our bodies for their own propagation. At the same time, the cartoon emphasizes that humans have acquired another mode of response-the use of technology-that allows us to combat diseases far more quickly (and with less suffering) than if we had to rely on a genetically determined evolutionary response. More subtly, the technology, institutions, and language (including humor) that make human societies what they are today all reflect a process of cultural evolution that emerged from, and now often overwhelms, its natural counterpart by virtue of the speed and flexibility of cultural systems. Finally, Trudeau jabs us with the needle of the conflict between evolutionary science and religion that dominates many discussions of evolution in the public sphere, at least in the United States, despite the overwhelming and continually growing body of evidence for evolution. For example, why might one group of people be more susceptible to a particular disease than another group? Why are some diseases more prevalent now than in the past, despite improved sanitation and increased access to food? In some cases, we must study the history of our own species to understand the mismatch between our present circumstances and those of our ancestors. Why do some pathogens and parasites make us very sick, or even kill us, when closely related microbes are harmless? For many years the "conventional wisdom" was that evolution would favor those parasites and pathogens that were harmless to their hosts. If parasites killed their hosts (so the thinking went), then they would drive their hosts and themselves to extinction. From this perspective, a highly virulent parasite was seen as a transient aberration, perhaps indicative of a pathogen that had recently jumped to a new host-one that would, over time, evolve to become less virulent if it did not burn out first. The antibiotics that scientific researchers and pharmaceutical companies developed to treat bacterial infections were hailed as a triumph of technology over nature. Only a few decades ago, the most dangerous infections were largely conquered in developed countries. Thousands of tons of antibiotics are used each year, causing intense selection for bacteria that can survive and grow in their presence. As a consequence, pharmaceutical companies must spend vast sums to develop new antimicrobial compounds that will allow us, we hope, to keep up with fast-evolving microbes. Meanwhile, emerging diseases that are new to humankind typically derive from pathogens that infect other animals. Investigators must identify the precise source of the microbes deployed in an attack, using evolutionary approaches similar to those used to track natural outbreaks. Humans and other farming species change the environment of domesticated species by providing them with shelter, nutrients, and reproductive assistance. Selection in this protective environment reshapes the morphology, physiology, and behavior of the domesticated varieties. While we usually think of the farmer as controlling the domesticated species, their relationship is effectively a mutualism; the farmer, too, may evolve greater dependence on agriculture. For example, humans have evolved an unusual trait among mammals that enables many (but not all) adults to continue to produce lactase, an enzyme that allows milk sugar to be digested. With the success of agriculture and other technologies, the human population has increased tremendously in size and, moreover, pushed into geographic areas that would otherwise be inhospitable to our species. As a result, humans have altered-by habitat destruction, introduction of nonnative species, and pollution-many environments to which other organisms have adapted and on which they depend, leading to the extinction of some species and threatening many others. For example, phylogenetic analyses are used to quantify branch lengths on the tree of life and determine, in effect, how much unique evolutionary history would be lost by the extinction of one species or another. Given limited resources for conservation efforts, this information can be used to suggest where those resources will have the biggest impact. Also, the mathematical framework of population genetics, which underpins evolutionary biology, is used in the management of endangered populations. In particular, captive-breeding programs and even the physical structure of wildlife preserves can be designed to maximize the preservation of genetic diversity and minimize the effects of inbreeding depression. Agriculture is the most familiar way in which humans use evolution for practical purposes, but it is not the only way. After a random library of sequences has been generated, sequences that have bound to the target are separated from those that have not.

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This decrease is Just above elbow Just below elbow At wrist 5 mV ­ + Conduction distance to medications without a script order 5mg dulcolax with mastercard hand treatment of tuberculosis 5mg dulcolax sale, millimeters: 419 Conduction time to counterfeit medications 60 minutes 5 mg dulcolax with visa hand, milliseconds: 13. Occasionally, sensory potentials can be low amplitude and associated with only mild sensory symptoms. In contrast to the change in amplitude, there usually is little change in latency or conduction velocity in axonal neuropathies; conduction in individual axons is generally normal until the axon has degenerated. Therefore, normal conduction velocities should not be considered evidence against the presence of neuropathy. Often, the only finding in a case of axonal neuropathy is fibrillation potentials on needle examination of distal muscles, especially intrinsic foot muscles. If many large axons are lost because of axonal neuropathy, conduction velocity may be decreased but not to less than 70% of normal. Axonal neuropathies typically affect the longer axons earlier and are first identified in the lower extremities. Nerves that are more susceptible to local trauma because of their superficial location are also more sensitive to axonal damage; sometimes, axonal neuropathies are manifested first as peroneal neuropathies with low-amplitude or absent responses, while other motor nerves remain intact. Axonal neuropathies may be associated with a change in the refractory period of the nerve and with a relative resistance to ischemia. Amyotrophic lateral sclerosis, a disease of anterior horn cells, shows changes on motor conduction studies typical of axonal neuropathy59 (Table 23­8) and is notable for large, repeater F waves resulting from collateral sprouting of axons. Demyelinating neuropathies typically are associated with prolonged latencies and a pronounced slowing of conduction, often in the range of 10­20 ms. In some hereditary disorders, such as Dejerine­Sottas disease, the velocity may be only a few meters per second. Table 23­8 Changes in Nerve Conduction Variables in Amyotrophic Lateral Sclerosis Changes Variable Compound muscle action potential Motor conduction velocity/F wave Motor distal latency Repetitive stimulation Subacute/active Normal unless severe Normal Normal Decrement in some Chronic active Low if severe <30% slow if severe <30% long if severe Decrement in some Inactive or residual Low if severe <30% slow if severe <30% long if severe Normal Compound Muscle Action Potentials 353 the electrophysiologic findings also vary among the inherited neuropathies, as shown in Table 23­9. The refractory period in demyelinating neuropathies is decreased, often to the extent that repetitive stimulation at rates as low as 5 Hz causes a decrement. The decrement usually does not appear, however, until rates of 10 or 20 Hz are used. The most common early electrophysiologic abnormalities are prolongation of the F wave, H wave, blink reflex, or distal motor latencies and temporal dispersion. A waves are particularly prominent in Guillain­ Barrй syndrome and are often the earliest sign of the disease on conduction studies. Electrophysiological features of inherited demyelinating neuropathies: A reappraisal in the era of molecular diagnosis. Facial nerves or other cranial nerves may be involved, with abnormalities seen on blink reflex testing or facial nerve stimulation. These criteria have been compared and it has been suggested that those originally proposed by Albers, et al. The Albers criteria include one of the following in two or more nerves: conduction velocity <95% if amplitude >50% of normal or <85% if amplitude <50% of normal, distal latency >110% if the amplitude is normal or >120% if the amplitude is less than normal, evidence of temporal dispersion (proximal > distal duration by 30%), evidence of conduction block (proximal to distal ratio of <0. In addition, F waves can recognize focal slowing proximally in addition to peripheral slowing from demyelination by comparing F-wave latency with F estimate. A longer F estimate than F latency signifies greater slowing proximal than distal. It is not possible therefore, without comparing the F latency to the F estimate, to determine if there is a greater degree of slowing and prolongation of the F-wave latency than would be expected from the degree of conduction velocity slowing. At the Mayo Clinic, we routinely compare F latencies to a calculated F estimate based on the distal conduction velocity. Although it may have other features of a generalized demyelinating neuropathy, the classic finding is that of conduction block, especially in the median nerve in the forearm. The conduction block can increase with activity81 and is hyperexcitable with fasciculation potentials. At times, the pattern of abnormality in demyelinating neuropathies helps differentiate an acquired process from a hereditary one. Acquired demyelinating disorders often show more dispersion with proximal stimulation than hereditary disorders do. Key Points · Diabetes can produce any of the variety of types of neuropathy: · · · · · Length-dependent, axonal sensorimotor, large fiber, peripheral Mixed axonal and demyelinating, peripheral Polyradiculoneuropathy Lumbosacral radiculoplexus neuropathy Single or multiple mononeuropathies. Conduction block and/or temporal dispersion and side-to-side conduction asymmetry favor acquired over inherited demyelinating neuropathy. Toxic and metabolic disorders are typically axonal neuropathies with greater sensory than motor involvement.

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The good news is that more recent work in cognitive evolution has recognized that phylogenetic and functional analyses require more precise and narrowly specified traits xerostomia medications side effects buy cheap dulcolax 5mg online. For example medicine 852 discount dulcolax 5mg without prescription, a number of scholars medications narcolepsy dulcolax 5 mg amex, such as Derek Bickerton, Terry Deacon, and Tecumseh Fitch, have recognized the need to decompose language into separate mechanisms, including computations for structuring words into sentences, mapping concepts to words, and articulating words with sounds or visual signs. Those interested in the evolution of music, such as Ray Jackendoff, Fred Lehrdahl, and Ani Patel, have appreciated the need to decompose this system into auditory perception, planning, memory, pattern analysis, and combinatorial computations, to name a few. Those interested in the evolution of mathematics, such as Susan Carey, Stanislas Dehaene, Randy Gallistel, and Elizabeth Spelke, have looked at different mechanisms of quantification, including those that rely on discrete and explicit symbols such as the integers, as well as those that do not; and the ways in which quantification relies on more general mechanisms of categorization, memory, and attention; and at how nonexplicit symbol systems for quantification evolve and develop into explicit ones. Students interested in cultural evolution, such as Robert Boyd and Michael Tomasello, have recognized the importance of looking at different mechanisms of transmission, including teaching, imitation, and observational learning, together with the importance of innovation, conformity, and social organization. From such decomposition, students of cognitive evolution have made great strides over the past 15 to 20 years. There are two important points to note about the cognitive decomposition approach. First, it starts with questions concerning the nature of a particular mechanism and then follows with questions related to adaptive function, including the socioecological conditions that favored its original expression. Consider, for example, the capacity for teaching, an ability that is observed in every human culture, in a wide variety of contexts, and is dependent on different cognitive processes. When humans teach, it is recognized that some individuals are ignorant and may want to learn. In other animals, teaching appears highly limited in taxonomic scope, and among those animals exhibiting some form of teaching, it appears limited to a single context. Thus, meerkats engage in a form of functional teaching in which adults help prepare pups to develop the skills to kill scorpion prey. It is a form of teaching in that the adults recognize a deficiency in young individuals and then break down the mature form of the skill into components to facilitate learning. Unlike humans involved in teaching, however, meerkats engage in this kind of pedagogy in only one context: predation on scorpions. At present, we lack a coherent account of why even this form of teaching does not occur in other functionally significant contexts among meerkats and why other species with similar social and ecological pressures lack teaching altogether. Second, the decompositional approach seeks to understand whether the mechanism in question evolved to solve a suite of general problems or a highly specific one while recognizing that a specialized mechanism can be co-opted for more general purposes. Three examples highlight the significance of this point: · the temporal lobe of the primate cortex evolved for object recognition, but in humans it has been co-opted for the added task of recognizing written word forms. These three cases illustrate why, for any given cognitive function in an organism, it is important to ask for what it evolved, for what it is presently used, for what it could be used, and whether each of these functions is general or specific to a particular problem. The comparative evidence available suggests that most cognitive functions observed in nonhuman animals have evolved for highly specialized problems and are restricted to use in this context. In many cases, we have inherited these highly adaptive capacities, but owing to evolutionary changes in the brain, coupled with the particular environments we inhabit, these specialized functions have been liberated, allowing us to tackle a much broader range of problems. In fact, it appears that many of our most revered cognitive capacities are by-products of a few specific 706 Evolution of Behavior, Society, and Humans select for hairless pets, reducing the mess at home and allowing those with allergies to enjoy the company of other animals? Some of these questions have already been asked and explored, generating a list of successes and failures. The failures reveal either the poverty of our imagination or the hidden constraints that limit the power of selection. Recent work on mammalian domestication provides an elegant illustration, especially with respect to the role of selection in both behavioral and cognitive evolution. Molecular evidence shows that the domestic dog first differentiated itself from its ancestor, the wolf, about 100,000 years ago. Dogs begin to appear in cave art, and the archaeological record more generally, between 14,000 and 16,000 years ago. Though there is little explicit information about the process of domesticating dogs, most scholars believe that as human populations adopted a more sedentary lifestyle, which included the introduction of agriculture, wolves started scavenging for food. Over time, this process initiated a cascade of morphological, physiological, behavioral, and cognitive changes that led to the first dog breeds. This first wave of change was followed by a second in which humans played an increasingly more directed role in creating new breeds, selecting for differences in size, coat coloration, temperament, and behavioral skills. Behavioral research in the last 10 years suggests that the process of domestication in dogs resulted in fundamental changes in cognitive ability-differences that are striking when contrasted with those of their close relatives, the wolves, and their more distant relatives, the nonhuman primates, including chimpanzees. There are two fundamental questions here: What critical differences in cognitive ability are specifically due to domestication?

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An organism can express only one of the six alternative developmental outcomes treatment zona buy dulcolax 5 mg with amex, depending on the specific inductive interactions that occur among cells during a critical moment in development medications requiring aims testing buy dulcolax 5mg free shipping. Continuous changes in genetic or environmental conditions can switch development from one pathway to medicine online order dulcolax 5 mg on-line another as shown. Species 1 expresses an aptation that originated by natural selection for a biological role that the character continues to serve. An exaptation, in contrast, is an aptation that serves a role other than one for which the character might be inferred to have evolved by natural selection. Gould and Vrba (1982) use as an example the utility of feathers for flight in birds. Phylogenetic analysis of birds and their fossil relatives shows that the origin of feathers preceded the origin of flight, thus rejecting the hypothesis that feathers could have originated by natural selection for enhanced flight. Feathers arose coincidentally with evolution of homeothermy in birds, favoring an explanation that feathers are an adaptation for thermoregulation but an exaptation for flight. Baum and Larson (1991) expanded this terminology to include the possibility that a character is deleterious relative to its antecedent condition. A primary disaptation is one whose lowered utility pertains to the environmental conditions under which the character arose, whereas a secondary disaptation is one that became relatively unfavorable following a subsequent change in environmental conditions. A primary disaptation usually signals processes analogous to natural selection that operate at the level of gene replication and transmission. For example, occurrence of a tailless condition in some mouse populations is associated with a genetic allele that produces tailless mice in the heterozygous condition and lethality when homozygous. The morphological condition is undoubtedly detrimental relative to the antecedent condition (normal development of the tail) in relevant populations. Nonetheless, during spermatogenesis in heterozygous individuals, gametes containing the tailless allele physically destroy those containing the contrasting allele (reviewed by Burt and Trivers 2006). Darwinian theory and its population-genetic models make clear that large geographic distributions and large amounts of genetic variation enhance the opportunities for a species lineage Concepts in Character Macroevolution 97 A C X2 F B D sp1 E A sp2 X1 B A Species 1 E Species 2 B B D F A D C C A B pathway D, which borders in parameter space all the other contrasting pathways. Species 2 expresses pathway A, which borders only pathways B and D in parameter space. Species 1 has a higher evolvability than does species 2 in this diagram because continuous changes in parameters X1 and/or X2 access a greater number of contrasting pathways than would comparable changes in species 2 (figure 3B). Figure 3C summarizes the relative evolvabilities of species expressing each of the contrasting developmental pathways. Relative evolvabilities of these pathways in decreasing order are D (five connections), C (four connections), B = E = F (three connections), and A (two connections). Note that although the parameter space is continuous, differences between the organismal morphologies represented by pathways A­F can be discontinuous (figure 3C). Figure 4A shows the skeletal structure of the hind foot characteristic of Ambystoma mexicanum. Figures 4B and 4C show alternative morphologies produced experimentally by treating the developing limb buds with the mitotic inhibitor colchicine, which alters inductive interactions in the developing limb. Both experimentally produced abnormal limbs match the normal limbs of distantly related salamander species. Hemidactylium scutatum (figure 4D) normally expresses the developmental pathway produced experimentally in A. These results show that Ambystoma mexicanum shares with each of the other species as a "deep homology" a developmental pathway normally expressed in the other species but latent in A. These alternative pathways could be, for example, those specifying contrasting hindlimb structures as illustrated in figure 4. Species 1 has parameter values specifying developmental pathway D, although it is near the critical thresholds for expressing pathways E and F. Thick arrows denote transformational changes more accessible than those depicted by thin arrows. On the basis of direct accessibility of alternative developmental pathways by changes in parameters X1 and X2, species expressing pathway D have the highest evolvability (five connections) and those expressing pathway A have the lowest evolvability (two connections), with pathway C having four connections and the remaining pathways each having three. Morphological outcomes of three alternative developmental pathways for the structure of the hind foot in salamanders. Morphologies B and C represent two alternative pathways activated by treating developing limb buds with the mitotic inhibitor colchicine. Morphology B resembles the normal condition expressed in the species Hemidactylium scutatum (morphology D). Morphology C resembles the normal condition expressed in the species Proteus anguinus (morphology E).

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Physician alerts should be built in to medications known to cause pill-induced esophagitis generic dulcolax 5 mg mastercard warn the prescriber if drug dosage is not within the therapeutic range medicine ball exercises buy 5mg dulcolax amex, or if a drug that is contraindicated in children is prescribed medicine used to treat bv dulcolax 5 mg with mastercard. Results management Ordering of investigations and results management should be integrated. Automated electronic reporting to the relevant public health agency may also be built in. In countries with advanced infrastructure for information technology, this is achievable with individual local health networks or clusters, as a starting point. Arriving patients require urgent treatment, and unless computer systems are linked, there is insufficient time to get information by paper records or telephone / fax. The American Academy of Paediatrics and American College of Emergency Physicians have jointly developed such forms downloadable 7 from the web. Paediatric specific data should be generated to aid clinical quality improvement and research. Chapter 4 describes how the different parts of the network in each region should integrate with each other. This may involve a random range of age groups, or a particular age group, depending on the circumstances. Some paediatric examples of patient surges could include, winter days when large numbers of paediatric patients present due to respiratory infection, or occasions where several very sick children arrive at once, after a school bus accident or a fire in a building. In more extreme cases, a regional incident may occur, as might occur during floods. The magnitude of an incident can be defined by the level of emergency response required to cope with it, rather than the absolute number of casualties. While some incidents may require only extra local resources, others will require regional, national or international resources. Major challenges of medical preparedness for disaster planning include: Pre-hospital and hospital preparedness for all the various scenarios Assimilation and retention of knowledge amongst healthcare personnel Assuring staff protection while caring for contaminated casualties Stockpiles of vital equipment and medications Planning for children as well as adults the goal for medical services managing patient surges is to ensure optimal care for all potential cases/incidents. The underlying principle is therefore "to do the greatest good for the greatest number". To achieve this goal, routine priorities may need to be modified depending on available resources. Differences between children and adults the delivery of optimal care to the paediatric population during patient surges, and especially during a disaster, requires advance planning, specialized care processes, specific resources, 1 and training beyond what might be required solely for adults. Unique physiological, physical, and psychological differences in children make them one of the most vulnerable populations during disasters. Children exhibit significantly higher mortality rates in disasters when compared to adults; this risk increases further for children under five 2-8 years. Yet on the other hand, there exists an expectation that during emergencies children should receive at least the same level of care (or greater) as that provided for adults. Many disasters involve children, so they must be incorporated into every stage of disaster planning. Managing paediatric patient surges / disasters Successful planning the key for successful management of paediatric victims is appropriate preparedness. This should include the following components: Pre-hospital and hospital preparedness at all levels (local, regional, national, international), for all potential hazards Clear identification of facilities that either will or will not receive infants, children and / or adolescents Adequate resources (especially equipment and medications) for children of all ages Medical and paramedical skills Conduction of practice disaster drills with sufficient paediatric victims to test readiness Caring for unaccompanied or orphaned children requires planning considerations for identification, tracking and reunification with family members or other trusted parties. Clinical management Triage assessment the normal challenges of communication and assessment of injuries and physiological parameters (see Chapter 6) are magnified during a disaster. In particular, accurate triage is difficult because conventional scoring systems use adult-based physiologic parameters and may rely upon cognitive and developmental abilities beyond those of young children. When overwhelmed, experience from some centres shows that a rapid visual inspection (see Chapter 6) by a senior member of staff, promotes appropriate casualty triage to the resuscitation area versus a secondary area, and this may have to substitute for measurements such as vital signs in the first instance. The Paediatric Assessment Triangle has been proposed as one such tool which uses visual inspection and can help rapidly triage 2 children. Regional networks must have systems to escalate the situation and access stockpiles of paediatric equipment and drugs.

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For example symptoms 2 days before period buy 5 mg dulcolax fast delivery, the bacterium Pseudomonas aeruginosa produces and secretes molecules that bind iron in way that allows the cell symptoms chlamydia buy discount dulcolax 5mg online, or other cells medications side effects prescription drugs generic 5mg dulcolax free shipping, to take it up. High relatedness structures favor secretion over nonsecretion, because some of the benefit of secretion goes to neighbors. These amoebas collectively produce a fruiting body in which 20 percent of the cells die to form a stalk, promoting the dispersal of the other 80 percent, which become spores. Genetic selection experiments have isolated numerous cheater mutants that produce excess spores, for example, by shirking on stalk production. When populations are maintained under low-relatedness conditions, it leads to the spread of mutants that cheat but cannot fruit on their own, even though the result is sharply declining spore production of the population. Under very high relatedness, however, groups are either nearly all wild-type cooperators, which do well in the absence of cheaters, or nearly all cheaters, which cannot produce spores without having cooperators to exploit. For example, birds growing up in a nest can generally count on each other being kin. The advantages potentially available through kin selection suggest that organisms should often have evolved mechanisms to explicitly recognize kin. This could be said to be one of the great predictions of kin selection theory, something that essentially started a new field. The prediction has been confirmed repeatedly across the tree of life, from microbes to mammals. A bird might learn who its nest mates are by proximity and then remember that information for later use after leaving the nest. In addition to remembering individuals, a more general mechanism of phenotype matching can be employed. Characteristic cues of known relatives (which could include self) are learned and remembered. Later Kin selection theory has revolutionized our understanding of cooperative social interactions. Ever more advanced models, phylogenetic comparative studies, and experimentation, including experimental evolution, support it. However, this does not mean kin selection has not faced challenges or that it can explain all forms of cooperation. Some beneficial effects on others are simply by-products of self-interested behavior. For example, when one parent benefits its own fitness by caring for its young, it also enhances the fitness of the other parent, who is typically unrelated. Secretion by a bacterium of products that help unrelated neighbors could still be favored provided the bacterium itself gets a net gain. This cooperation can be explained as reciprocal altruism, which requires direct or indirect payoffs to the actors. The kinds of accounting and retaliation necessary for reciprocal altruism to work make it unlikely in most animals, but there are still other ways of cooperating for immediate direct benefits. For example, in a lichen mutualism, the fungus provides structure and protection, while the alga provides carbon. The key difference between all these other forms of cooperation and kin-selection cooperation is that the former all require direct benefits to the actor. Only kin selection can lead to true altruism, where there is a fitness cost to the actor that is not repaid. Since inclusive fitness includes not just kin benefits but also direct benefits to self, it can account for all these forms of cooperation. There is a kind of true altruism that involves some individuals helping others with no evident selfish gain to their soma, or to their genes. This is the kind of thing that kin selection predicts should not be favored by selection, so if it were pervasive, it would mean trouble for kin selection theory. Unicoloniality is a feature of sociality in a small number of ant species that appears to break all rules.

References:

  • https://www.seymourjohnson.af.mil/Portals/105/Documents/MDG%20Docs/AFI%2048-123.pdf?ver=2016-02-17-110439-997
  • https://www.healthinfotranslations.org/pdfDocs/ActiveLegROMstanding_Sp.pdf
  • https://www.hrw.org/reports/US941.pdf